Coenzyme Q10 modulates sulfide metabolism and links the mitochondrial respiratory chain to pathways associated to one carbon metabolism

Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism.

AKAP121 focuses distinct signaling events from membrane to mitochondria by binding and targeting cAMP-dependent protein kinase (PKA), protein tyrosine phosphatase (PTPD1), and mRNA. We find that AKAP121 also targets src tyrosine kinase to mitochondria via PTPD1. AKAP121 increased src-dependent phosphorylation of mitochondrial substrates and enhanced the activity of cytochrome c oxidase, a compo...

Mitochondrial AKAP121 links cAMP and src signalling to oxidative metabolism

AKAP121 focuses distinct signalling events from membrane to mitochondria by binding and targeting cAMP-dependent protein kinase (PKA), protein tyrosine phosphatase (PTPD1) and mRNA. We find that AKAP121 also targets src tyrosine kinase to mitochondria via PTPD1. AKAP121 increased src-dependent phosphorylation of mitochondrial substrates and enhanced the activity of cytochrome c oxidase, a compo...

Carbon metabolism of Beauveria bassiana may be related to virulence against Plutella xylostella and Leptinotarsa decemlineata

Synthesis of adenine-B12 coenzyme by Clostridium sticklandii: relationship to one-carbon metabolism.

A member of the vitamin B12 group has been identified as the red chromophore of reddish brown enzyme fractions obtained from Clostridium sticklandii. An orange compound which appears to be identical with the coenzyme form of pseudovitamin B12 (or adenine-B12 coenzyme) discovered by Barker et al. (Proe. Natl. Acad. Sci. U. S., 44, 1093, 1958) is obtained if preparations are protected from visibl...

Mitochondrial one-carbon metabolism maintains redox balance during hypoxia.

Mitochondria generate high levels of reactive oxygen species (ROS) to activate protumorigenic signaling pathways. In parallel, the mitochondria must also increase their antioxidant capacity to lower ROS levels and prevent cancer cell death. In this issue of Cancer Discovery, Ye and colleagues demonstrate that serine catabolism through one-carbon metabolism within the mitochondrial matrix is nec...